Vaccinations with Live Attenuated Virus Vaccines: Immunoglobulin administration may impair the efficacy of live attenuated virus vaccines eg, measles, rubella, mumps and varicella vaccines for a period of up to 3 months. Human hepatitis B immunoglobulin should be administered 3-4 weeks at the earliest after vaccination with such a live attenuated vaccine; in case administration of human hepatitis B immunoglobulin is essential within 3-4 weeks after vaccination, then revaccination should be performed 3 months after the administration of human hepatitis B immunoglobulin.
Interference with Serological Testing: It has to be considered that when serological test results are interpreted, the transitory rise of passively transferred antibodies after immunoglobulin injection may result in misleading positive test results.
Passive transmission of antibodies to erythrocyte antigens eg, A, B and D may interfere with some serological tests for red cell allo-antibodies (eg, Coombs' test).
Incompatibilities: In the absence of compatibility studies, Hepatitis B Immunoglobulin P Behring must not be mixed with other medicinal products, diluents or solvents.